Cardiac aging is accompanied by progressive loss of cellular function, leading to impaired heart function and heart failure. There is an urgent need for efficient strategies to combat this age-related cardiac dysfunction. A growing number of events suggest that age-related cardiac diseases are tightly related to metabolic imbalance. This review summarizes recent findings concerning metabolic changes during cardiac aging and highlights the therapeutic approaches that target metabolic pathways in cardiac aging...Oral administration of NR has been shown to increase NAD+ levels in humans. Moreover, NR can prevent the deterioration of cardiac function and adverse remodeling in a mouse model of dilated cardiomyopathy