Nicotinamide (NAM) was evidenced to have the capacity to improve energy metabolism and attenuate oxidative stress during the perinatal period. As there is an association between maternal nutrition and the developmental outcomes of offspring, the aim was to investigate the effect of maternal NAM supplementation on small intestine morphology and some antioxidative parameters of offspring kids. ... Thus, these data indicated that maternal NAM supplementation improved the small intestinal development of offspring kids partially by affecting the antioxidative status and milk metabolites of the does. This knowledge further suggested that the development of a nutritional strategy from prepartum period and milk feeding in early life are important for offspring kids.