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Axonal Protection by Oral Nicotinamide Riboside Treatment with Upregulated AMPK Phosphorylation in a Rat Glaucomatous Degeneration Model

Current Issues in Molecular Biology

August 25, 2023

Arizono, Ibuki

Summary

We confirmed that oral NR administration significantly increased NAD+ levels in the retina. ...Oral NR administration significantly prevented retinal ganglion cell (RGC) fiber loss in retinal flat mounts...Our findings suggest that oral NR administration protects against glaucomatous RGC axonal degeneration with the possible upregulation of p-AMPK...A recent study showed reductions in Nampt, Nmnat1, and Nmnat2 in RGCs in glaucoma patients, implying that not only the NAD+ level but also the NAD salvage pathway can be reduced in glaucoma.

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I am Shelly Albaum, and this is my personal website and blog. All the opinions presented here are my own. Nobody writes here but me. You can read more about me here. Cookies are not required to use this website. Read more about that here. 

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Original work © 2022 by Right of Assembly

No claim to research or any work of others

IMPORTANT DISCLOSURES

1. Health Supplements Are Not Medicines. Health Supplements that raise NAD levels, like nicotinamide riboside or other NAD precursors, are not intended to diagnose, treat, cure, or prevent any disease.

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2. No Medical Advice. I am a lawyer and a journalist, not a doctor, and I offer no medical advice. But I do follow the science, and I can bring to your attention some interesting studies. You can read more about me here. And check with your physician -- your physician can look at this research, too.

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